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Research suggests it plays a role in modulating the hypothalamus, influencing neurotransmitters such as GABA, serotonin, dopamine, and noradrenaline

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Beyond POTS, autonomic dysfunction in long COVID can present as: Dysregulated sweating Impaired gastrointestinal muscle contractions, causing constipation, pain, nausea, or weight loss Temperature dysregulation An exaggerated fight-or-flight response The vagus nerve within this systemthe primary parasympathetic nerve connecting the brain to the gut, heart, and lungsappears to be particularly vulnerable to COVID-19-related damage, with implications for heart rate variability, gut function, and the inflammatory regulatory role the vagus nerve normally performs

Improved Sleep and Systemic Recovery Secretagogues like MK-677, CJC-1295, and Ipamorelin also enhance sleep architecture, particularly slow-wave (deep) sleep the stage where most muscle and connective tissue repair occurs

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